Stochastic simulation of prokaryotic two-component signalling indi- cates stochasticity-induced active-state locking and growth-rate de- pendent bistability - Supplementary Information

Parameter Estimate Reaction k1f 0.01 nM−1 s−1 S+L → SL k1b 0.059 s−1 SL → S+L k2 0.1 s−1 SL (+ATP) → SLP (+ADP) k3f 0.001 s−1 SLP → SP k3b 0.001 s−1 SP → SLP k4f 0.0238 nM−1 s−1 SLP+R → SLP·R k4b 0.001 s−1 SLP·R → SLP+R k5f 0.0238 nM−1 s−1 SP+R → SP·R k5b 0.001 s−1 SP·R → SP+R k6f 19.8 s−1 SLP·R → SL+RP k6b 0.001 nM−1 s−1 SL+RP → SLP·R k7f 19.8 s−1 SP·R → S+RP k7b 0.001 nM−1 s−1 S+RP → SP·R k8f 0.0238 nM−1 s−1 S+RP → RP·S k8b 0.2 s−1 RP·S → S+RP k9 0.5 s−1 RP·S → S+R (+Pi) k10f 0.001 s−1 SLP·R → SP·R k10b 0.001 s−1 SP·R → SLP·R k11 0.0001 s−1 RP → R (+Pi) k12 0.0001 s−1 SP → S (+Pi) k13 0.0001 s−1 SLP → SL (+Pi)